Tuesday, 16 December 2025

Solvents that can be Dried Using the Water Azeotropes

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  In a previous blog article, the point was made that drying organic solvents with solid desiccants would contaminate the entire filter trai...
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Monday, 15 December 2025

Binary Azeotropes of Common Organic Solvents Potentially Useful for Crystallization

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    Example 1of US patent 3,932,384 awarded to Sawa et al. reads:   “The resulting crude base (17.4 g) is passed through a column of 87 g...
Friday, 5 December 2025

Preferred Solvent for Synthesizing a Compound that can be Reversibly Extracted into Water.

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  Suppose I were presented with the problem of synthesising an organic compound that can be reversibly extracted into water at some pH (ie,...
Monday, 1 December 2025

Building Organic Chemistry Synthetic Processes Retrosynthetically

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To develop a synthetic process the chemist needs a sequence of chemical reactions and their work-ups, isolations, and intermediate purific...
Friday, 14 November 2025

Preparing a Resolution Standard for Use to Validate the Analytical Method for an Active Pharmaceutical Ingredient (API)

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  No analytical method can be proven able to identify all potential impurities in a sample. What can be demonstrated is that a refined metho...
Wednesday, 26 March 2025

A Proposed Cheap Replacement for Quinoline -3-carboxylic acid as a Reversible Tag

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  In 1999, Hélène Perrier and Marc Labelle [J. Org. Chem. 1999, 64 2110-2113 ] proposed using a 3-quinolinecarboxylate protecting group on a...
Saturday, 22 March 2025

KiloMentor Process Development Strategy Reviewed

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  KiloMentor | revised 6th  January 2009 republished February 17/2017 and March 22nd 2025 This is a revision of one of the earliest articles...