Wednesday, 26 March 2025

A Proposed Cheap Replacement for Quinoline -3-carboxylic acid as a Reversible Tag

›
  In 1999, Hélène Perrier and Marc Labelle [J. Org. Chem. 1999, 64 2110-2113 ] proposed using a 3-quinolinecarboxylate protecting group on a...
Saturday, 22 March 2025

KiloMentor Process Development Strategy Reviewed

›
  KiloMentor | revised 6th  January 2009 republished February 17/2017 and March 22nd 2025 This is a revision of one of the earliest articles...
Sunday, 29 December 2024

The Advantages of Ethanol-Cyclohexane Mixtures as Organic Reaction Solvent Media

›
In designing process steps for fine chemical synthesis a bias has existed against multi-component solvent systems. In the past, it was argue...
Saturday, 28 December 2024

The Advantage of Methanol-Hydrocarbon Solvent Mixtures for Organic Synthesis

›
This blog article is speculative. It is not based on experimental data. However, the information about the compositions and boiling points ...
Friday, 27 December 2024

When Scaling Up a Synthetic Organic Intermediate that is being Purified by Distillation

›
If an intermediate is being worked up, isolated, or purified by distillation as part of developing a chemical process for synthesis at sca...

Mixtures of Acetonitrile, Ethylene Glycol, and Water in a Liquid-Liquid Extraction of Polar Impurities from Mixtures in Hydrocarbon Solvents

›
  It is quite well known that acetonitrile and any hydrocarbon liquid upon mixing together will separate into two layers. It is very much ...
Monday, 27 May 2024

The Portfolio Method of Chemical Process Development

›
More efficient chemical process development is possible but it requires the addition to the team of someone with an unusual combination of ...