Saturday, 18 February 2017

Drying of Process Intermediates

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In performing a single step process, the product is typically dried to constant weight because for a final product you want a...

Improving Recovery from Crystallization

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KiloMentor consistently advocates a preference for scaling-up processes that are designed, as much as possible, to use intermediate...

Advantages Filtering Solids at Scale

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Crystallization in the laboratory is rarely performed under an inert atmosphere. Most commonly, crystal filtration is done in the open air ...
Friday, 17 February 2017

Swishing and Swish TLC: The Most Important Analytical Paper Ever for Chemical Process Development

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In KiloMentor’s assessment, the most important analytical paper in the literature in terms of usefulness to process development chemists ...

Byproducts, Side-products, and Co-products.

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A co-product is defined in the KiloMentor Blog as follows; A co-product is a product created according to the stoichiometry of a balanced...

Separation as the Focus of Chemical Process Development

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KiloMentor | revised 6th  January 2009 republished February 17/2017 This is a revision of one of the earliest articles from the Kil...
Monday, 13 February 2017

Unknown Intransigent Chemical Impurities in Pharmaceuticals: Their Qualities and their Treatments

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The Intransigent Impurity In developing a process, improvement very often only proceeds to an outcome satisfactory from a cost, scale, ...