Showing posts with label treating impurities. Show all posts
Showing posts with label treating impurities. Show all posts
Sunday, 29 November 2020

Exhaustive Digestion as a Simple Prelude to High Yield Crystallization

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  This article is about the technique I call ‘exhaustive digestion’. This is a phrase that I used in my blog entitled, Getting Better Recov...
Wednesday, 11 November 2020

Genotoxic Impurity Considerations

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Genotoxicity is the capacity of a substance to damage genetic material such as DNA, and thus cause mutations or possibly cancer. Genotoxic i...
Tuesday, 22 September 2020

How does one Produce the Most Likely Impurities in the Product from a Process Step?

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I n order to develop a good purity analysis for an organic substance, one needs to have some method to assess different methods. A better ...
Monday, 1 June 2020

Use of free radical inhibitors or antioxidants to increase the overall yield of organic synthesis steps

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The use of radical inhibitors or antioxidants to improve yields does not appear to have many precedents in organic synthesis. A key...
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Wednesday, 20 November 2019

Strategies for Characterizing Trace Impurities Important for Regulatory Compliance in Pharmaceutical Synthesis

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In setting the specifications for a pharmaceutical substance, its unknown impurities must typically be less than 0.1% area/area with r...
Sunday, 17 November 2019

Liquid-Liquid Extraction using Hydrotropes as an Alternative to Fractional Crystallization for Purification at Scale

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How does one purify a mixture of structurally similar neutral compounds that is about 80% one isomer and 20% the other?  If you adopt...
Saturday, 16 November 2019

Producing the most likely impurities of a Given Product for Use in Developing a Powerful Analytical Method

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In order to develop a good purity analysis for an organic substance one needs to have some method to assess different methods. The bet...
Sunday, 3 November 2019

Removal of Hydroxyl Impurities from a Solid Product at Scale by Chemical Reaction

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KiloMentor has several times proposed the purification of a substance by selective reaction of its impurities to produce new impuriti...
Monday, 21 October 2019

Thiazolidinedione as a Potential Reagent for eliminating Carbonyl Impurities from a Reaction Mixture: Purification by Reaction and Extraction

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The development of the glitazones (pioglitazone, rosiglitazone etc.) as  drug substances has reduced the price of 2,4-thiazolidine-2,4-d...